Using planarian flatworms to understand organ regeneration

ScienceDaily (Oct. 25, 2012) ? In a new study published in the Oct. 16 issue of Developmental Cell, corresponding author Professor of Cell and Developmental Biology and Howard Hughes Medical Institute Investigator Phillip Newmark and colleagues report the identification of genes that control growth and regeneration of the intestine in the freshwater planarian Schmidtea mediterranea.

How animals repair their internal organs after injury is not well understood. Planarian flatworms are useful models for studying this question. After injury, they are able to re-grow missing body parts, as well as all as organs that are damaged or lost, such as brain, eyes, and intestine.

Injury initiates a complex set of cellular events. In planarians, specialized somatic stem cells called neoblasts divide and give rise to all of the different cell types required to rebuild fully functional body parts. Old tissue remaining after amputation remodels and integrates with the new cells that are produced.

The molecular signaling pathways coordinating these cellular behaviors to achieve organ regeneration have not been well characterized. David Forsthoefel, a postdoctoral researcher in Newmark's laboratory and the lead author on the study, wanted to address the problem using the planarian intestine as a "model organ," in part because so few animals are capable of repairing severe damage to their digestive systems.

"The ability to recover from loss of digestive tissue is rare in the animal kingdom," Forsthoefel said. "What we learn from how a simple worm deals with gut damage might one day help us to come up with better medical therapies, for example in the treatment of short bowel syndrome, in which segments of intestine must be removed from patients with digestive diseases, leading to impaired nutrient absorption."

Forsthoefel developed a method for purifying a single intestinal cell type from the planarian gut. He and Newmark lab members then went on to identify over a thousand genes that were uniquely expressed at higher levels in intestinal cells than in the surrounding planarian tissues. Guessing that some of these genes would have important roles during intestinal growth and regeneration, they probed the function of a subset of these genes using a technique called RNA interference, in which the expression of individual genes is selectively inhibited. They were able to pinpoint functions for specific genes, for example in the establishment of the appropriate pattern of intestinal branches, and the production of functional intestinal cells capable of taking up nutrients.

The authors also identified a transcription factor called nkx-2.2 that, although expressed in the intestine, was required for neoblasts to proliferate in various contexts, including after injury. This result suggests a potential role for the intestine in regulating stem cell division, a result Forsthoefel is following up by identifying genes downstream of Nkx-2.2 that might have more direct roles in communication between the intestine and neoblasts.

"How cells in the vicinity of damaged tissue contribute to the choices stem cells make in response to injury is an area of regeneration biology where much more research is needed," Forsthoefel said.

The field of regeneration research is rife with such uncharted territory. How do animals manage to produce the correct number specific cell types, at the correct locations? What are the signals that instruct stem cells to become specific cell types, and where do they come from? How is organ-specific morphology, for example the number of intestinal branches, determined? This study from the Newmark lab, the first systematic effort to elucidate intestinal morphogenesis in planarians, lays the groundwork for addressing many of these fundamental questions of organ regeneration.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by School of Molecular and Cellular Biology, University of Illinois, Urbana.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. David?J. Forsthoefel, No?lle?P. James, David?J. Escobar, Joel?M. Stary, Ana?P. Vieira, Forrest?A. Waters, Phillip?A. Newmark. An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians. Developmental Cell, 2012; 23 (4): 691 DOI: 10.1016/j.devcel.2012.09.008

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/wW1Dh7Xm4No/121025122618.htm

beginners 2012 oscars the shore meryl streep oscar wins sasha baron cohen oscars oscar winners the artist

Political wack pack: The oddest candidates of 2012

In a bid to reach more voters, the Libertarian Party's candidate for a Kansas congressional district changed his name over the summer?to Thomas Jefferson.

"Whether you think it's crazy or not, hopefully it gets people thinking about the founding fathers and Thomas Jefferson in particular and whether we have that form of government still," Jack Talbert, now legally Jefferson, told the Topeka Capital-Journal.

His goal, according to the Libertarian

... more?

In a bid to reach more voters, the Libertarian Party's candidate for a Kansas congressional district changed his name over the summer?to Thomas Jefferson.

"Whether you think it's crazy or not, hopefully it gets people thinking about the founding fathers and Thomas Jefferson in particular and whether we have that form of government still," Jack Talbert, now legally Jefferson, told the Topeka Capital-Journal.

His goal, according to the Libertarian Party of Kansas website, is to "launch the Thomas Jefferson Project ... an effort to end gridlock due to party differences by introducing the concept of voting for the person, not the party."

(Photo and portrait of Thomas Jefferson by Reuters/National Portrait Gallery. Photo of Thomas Jefferson [Jack Talbert] via Wikimedia Commons.)

less?

Source: http://news.yahoo.com/photos/political-wack-pack-the-oddest-candidates-of-2012-1350687123-slideshow/

jennifer hudson tribute to whitney houston nicki minaj grammy jason whitlock beach boys tony bennett joe walsh the civil wars

Google cameras map popular Grand Canyon trails

In this Monday Oct. 22, 2012, photo, Google product manager Ryan Falor walks with the Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

In this Monday Oct. 22, 2012, photo, Google product manager Ryan Falor walks with the Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

In this Monday Oct. 22, 2012, photo, Google product manager Ryan Falor works with the Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

This Monday Oct. 22, 2012, photo shows the mast of Google's Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

In this Monday Oct. 22, 2012, photo, Google operations manager Steve Silverman stands along the canyon wall wearing the Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

In this Monday Oct. 22, 2012 photo, Google operation manager Steve Silverman is silhouetted against a canyon wall as he poses with the Trekker during a demonstration for the media along the Bright Angel Trail at the South Rim of the Grand Canyon National Park in Arizona. The search engine giant is using the nearly 40-pound, backpack-sized camera unit to showcase the Grand Canyon?s most popular hiking trails on the South Rim and other off-road sites. It?s about 4 feet in height when set on the ground, and when worn, the camera system extends 2 feet above the operator?s shoulders. (AP Photo/Rick Bowmer)

GRAND CANYON NATIONAL PARK, Ariz. (AP) ? Google and its street-view cameras already have taken users to narrow cobblestone alleys in Spain using a tricycle, inside the Smithsonian with a push cart and to British Columbia's snow-covered slopes by snowmobile.

The search giant now has brought its all-seeing eyes ? mounted for the first time on a backpack ? down into the Grand Canyon, showcasing the attraction's most popular hiking trails on the South Rim and other walkways.

It's the latest evolution in mapping technology for the Mountain View, Calif., company, which has used a rosette of cameras to photograph thousands of cities and towns in dozens of countries for its Street View feature. With a click of the mouse, Internet users are transported virtually for a 360-degree view of locales they may have read about only in tourist books and seen in flat, 2-D images.

"Any of these sort of iconic, cultural, historical locations that are not accessible by road is where we want to go," said Ryan Falor, product manager at Google.

Google announced the trekker earlier this year but made its first official collection of data this week at the Grand Canyon.

The backpacks aren't ready for volunteer use, but Google has said it wants to deploy them at national forests, to the narrow streets of Venice, Mount Everest and to ancient ruins and castles.

The move to capture the Grand Canyon comes after Apple chose to drop Google Maps from its mobile operating systems and opted to use its own mapping program that was derided for, among other things, poor directions and missing towns.

Steve Silverman, operations manager for Google didn't directly address the competition in saying: "Just trying to document a trail, it's going to be hard to beat this."

Google launched its Street View feature in 2007 and has expanded from five U.S. cities to more than 3,000 in 43 countries. Google teams and volunteers have covered more than 5 million miles with the Street View vehicles on a scale that other companies haven't approached, said Mike Dobson, president of Telemapics, a company that monitors mapping efforts.

"You could safely say that it's a standout, well-used application and they don't really have any competition," he said.

As the sun rose Monday, Luc Vincent, Google engineering director, strapped on one of the 40-pound backpacks and set down the Bright Angel Trail to the Colorado River ? a nearly 10-mile hike that goes from 6,900 feet in elevation to 2,400 feet. He hiked back up from Phantom Ranch, which can be 30 degrees warmer than at the rim, through the South Kaibab Trail and also gathered data on other trails.

The so-called trekker captures images every 2.5 seconds with 15 cameras that are 5 megapixels each from the rest areas, the steep switchbacks, the change from juniper trees to scrub brush and the traffic that moves aside as a courtesy to mule riders.

The GPS data is limited, so Google must compensate with sensors that record temperature, vibrations and the orientation of the device as it changes, before it stiches the images together and makes them available to users in a few months, Falor said.

Hikers that were on the trail when the data was gathered will have their faces blurred ? an attempt by Google to ensure privacy. Street View has run into problems in places like Europe and Australia for scooping up information transmitted over unsecured wireless networks.

A removable hard drive on the trekker stores the data gathered at the Grand Canyon. Tourists looked at the trekker strangely this week, as if it was something from outer space.

Sharon Kerfoot, a first-time visitor from Alberta said being able to view the terrain ahead of time, gauge the difficulty of the hike and know just how wide the path is would benefit those considering a trip to the Grand Canyon. She and a group of friends headed down the same path as Vincent but on mules, not foot.

"I think it's an excellent idea to give people a broader perspective on what they're getting into," she said.

What the images won't tell visitors is how much water they should carry down the trails, how to prepare for temperature changes, what type of food to take and how much, and how best to protect the natural resources, park spokeswoman Maureen Oltrogge said.

"Stitched together with other information out there, the technology could be valuable," she said.

___

Follow Felicia Fonseca on Twitter: http://www.twitter.com/FonsecaAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-10-24-Google-Grand%20Canyon/id-cf5d0b5fbb4746669b13b9ad641c23f2

nfl 2012 schedule gmail down ryan oneal file taxes online tupac shakur sledge hammer tax day freebies

Markets subdued as focus remains on US

LONDON (AP) ? Financial markets were on the defensive Tuesday ahead of another round of U.S. corporate earnings, including from Facebook, and amid uncertainty over the outcome of the U.S. presidential election.

The U.S. has been center stage this week as the earnings season continues and as the election looms. So far earnings have been mixed, particularly from the technology sector.

"We are currently in the third week of a disappointing corporate earnings season," said Craig Erlam, market analyst at Alpari.

Facebook's earnings results after the market close will be key for its future. The social network has had a dire time since its stock flotation earlier this year, losing over a third of its value, as investors have grown concerned about the company's ability to raise money from advertising.

"The results have the potential to make or break Facebook as an investment," said Erlam.

Over-arching the focus on earnings is the battle for the White House, with opinion polls showing the two candidates are in a dead heat. Last night's debate between President Barack Obama and Mitt Romney appears to have done little to change that.

Meanwhile, the Federal Reserve starts its regular two-day policy meeting Tuesday but little is expected in the midst of the election.

By late morning in Europe, Germany's DAX was down 0.9 percent at 7,265 while the CAC-40 in France fell 0.6 percent to 3,464. The FTSE 100 index of leading British shares was down 0.8 percent at 5,837.

Wall Street was poised for a lower opening, with Dow futures down 0.5 percent and the broader S&P 500 futures 0.7 percent lower.

In Europe, there was little scheduled news regarding the debt crisis to drive investor sentiment. Over the past few weeks, markets have been shored up by hopes that Spain will soon tap a new bond-buying facility from the European Central Bank and expectations of further stimulus measures from Beijing.

"With the main market drivers being a Spanish bailout request and substantial Chinese stimulus being largely priced in and having not come to pass, investors are growing increasingly nervous," said Mike McCudden, head of derivatives at Interactive Investor. "Furthermore, without another EU Heads of State meeting until mid-December there is growing concern that we will not see any progress in the eurozone until then."

Earlier in Asia, stock indexes fared slightly better. Japan's Nikkei 225 index eked out a marginal gain to close at 9,014.25 a day after the country's currency fell to a three-month low against the dollar.

A weak yen helps Japan's mammoth export sector by raising the value of company profits repatriated from abroad. Still, grim export data ? which Monday showed a 10 percent drop in exports for September compared with a year earlier ? kept advances in check.

South Korea's Kospi declined 0.8 percent to 1,926.81 but mainland Chinese stocks lost ground, with the Shanghai Composite Index down 0.9 percent to 2,114.45. The Shenzhen Composite Index lost 1.4 percent to 869.96.

Hong Kong markets were closed for a public holiday.

In the currency markets, the euro was down 0.3 percent at $1.3033 ? the euro often suffers when investor appetite for taking on risk is diminished.

As do oil prices ? benchmark oil for December delivery was down 14 cents to $88.51 per barrel in electronic trading on the New York Mercantile Exchange.

Source: http://news.yahoo.com/markets-subdued-focus-remains-us-104838776--finance.html

andrew luck andrew luck trent richardson robert griffin iii dontari poe space shuttle nyc monkeypox

Election's other crystal balls: Football, baseball, basketball

Washington (CNN) ?

Why invest in polling and television ads, when rooting for a few oddly dispersed teams can lead to presidential victory?

Election watchers have been looking for correlations between sports and the presidency for years. A few have been found, explaining why challengers should root for the Washington Redskins, Democrats should root for the National League baseball teams and Republicans should cheer for the Los Angeles Lakers.

The most well known sports related presidential predictor is the Redskin's Rule. The rule is simple: if the Redskins lose, the challenger wins; if the Redskins win, the incumbent wins. Since 1940 (the 'skins moved to Washington in 1937), the outcome of the Redskins last home game before the election has correctly predicted the outcome of the presidential election 17 out of 18 times.

The Redskins play the Carolina Panthers at home on November 4, just two days before the election.

If you believe the rule, Obama will be cheering for the Redskins and Romney will be cheering for the Panthers.

Major League Baseball, in a press release, noted another correlation from the twenty-six World Series played since 1908, albeit a less reliable one.

About three-fifths (59%) of the time that the American League team won the World Series, the Republican candidate won the White House. Likewise, 67% of the time that the National League won the World Series, the Democrat won the White House.

After a long season, the National League's San Francisco Giants will face off against the American League's Detroit Tigers in the World Series starting on Wednesday. If the odds hold, Romney - a native of Michigan - will be pulling for the team from Detroit, while Obama will be pulling for the Giants.

Though not totally accurate, this theory has correctly predicted the last three elections.

But that is not all - the United States is more sports and politics obsessed than just two theories.

Source: http://www.wmur.com/news/politics/Election-s-other-crystal-balls-Football-baseball-basketball/-/9857748/17101112/-/8jkcnvz/-/index.html?absolute=true

Colorado fires supreme court college board summer solstice Summer Solstice 2012 Waldo Canyon fire nba finals

GOP's McMahon ad targets Conn. Obama voters

HARTFORD, Conn. -- GOP Senate candidate Linda McMahon is courting ticket-splitters in a new ad in which four supporters of President Barack Obama, who has a double-digit lead in the state, say they also will cast ballots for her. Her campaign strongly denied she was writing off Republican presidential hopeful Mitt Romney, saying she supports the former Massachusetts governor "100 percent."

"Linda McMahon will work with President Obama and I believe he'll work with her," says one of the voters in the ad, David Cole, a disabled veteran who said he plans to vote for the Republican on the independent line in November. McMahon's name will appear as both the Republican and the Independent candidate.

Nonsense, said Rep. Chris Murphy, the Democrat in the race once thought to have a better shot at winning.

"This is one of the strangest political ads I have ever seen because we know that Linda McMahon is going to oppose President Obama on everything that he stands for. She's told us that, over and over again," said Murphy, referring to the Republican candidate's calls to repeal and replace Obama's health care legislation and her opposition to his positions on energy reform and tax policy. "I mean, there is almost nothing Linda McMahon agrees with President Obama on, which makes this ad absolutely deceitful."

It was the latest volley in one of the nation's quirkiest Senate races, one of a series of stubbornly tied contests that have left the national battle for control of the Senate in question. Republicans need to gain three seats, or four if Obama wins. From Massachusetts to Connecticut, Virginia, Indiana, Missouri, Wisconsin, North Dakota, Montana, Nevada and Arizona, contests for Senate are so tight that with two weeks to go, the parties, candidates and outside groups are doling out cash and getting creative about peeling votes away from the other guy.

With McMahon's ad, Connecticut joins Senate races in which candidates are banking on voters choosing candidates of different parties down the ticket. In places like Montana and North Dakota, the politics are reversed, with Romney expected to win big and Democratic Senate hopefuls making their pitches as independent-minded candidates.

In Connecticut, the candidates are racing to win the seat of a retiring senator who counted himself an independent: Sen. Joe Lieberman, who caucused with the Democrats.

The state has a vibrant independent streak. As of last week, the Secretary of the State's Office reported 2 million registered voters in Connecticut, with the largest group, 842,335, being unaffiliated. They are followed by registered Democrats, at 744,729 and registered Republicans at 422,312.

McMahon's ad rankled Republicans, after they chose the former wrestling empire executive over former Rep. Christopher Shays in the August primary. McMahon lost in 2010 to then-Attorney General Richard Blumenthal after spending more than $50 million of her own money. She has so far personally spent some $27 million on this year's race. State GOP Chairman Jerry Labriola said the Connecticut Republican Party headquarters has been "experiencing very high call volume in response to the ad," with Republican "expressing serious concerns."

"It's a distressing situation, but we're doing our best to deal with it," he said, adding how he still believes Romney can win in Connecticut and how he's "working very hard to get to elect all Republicans on the top line of the ballot this November."

McMahon's campaign spokesman, Todd Abrajano, said the campaign has not received a large number of complaints.

"I think most people realize that in the state of Connecticut, if you're a Republican running statewide, you're going to have to get independents and Democrats to vote for you in order to win," said Abrajano.

Abrajano said McMahon supports the GOP presidential ticket "100 percent" and is not encouraging people to vote for Obama, who is expected to win relatively easily in Connecticut. However, if Obama wins, he said McMahon is willing to work with him.

Bill Heyn, a 70-year-old retiree from New Canaan who attended a McMahon rally on Monday in Stamford featuring New Jersey Gov. Chris Christie, said he understands why McMahon is running such an ad.

"It makes sense. She's got to get somebody to cross over," he said. "She's trying to win."

Source: http://www.miamiherald.com/2012/10/22/3061953/gops-mcmahon-ad-targets-conn-obama.html

black panthers mauritania mark sanchez obama open mic jefferson county colorado extenze tenacious d

Kickboxing Gym in Phoenix Offers Lose Weight Workout

Want to lose weight and keep it off? ?Phoenix Kickboxing Instructor Shows You Exactly How...

My name is John Nottingham and I've been training people, just like you, how to get in the best shape of their lives with kickboxing lessons for over 27 years. ?The only proven way to lose weight and keep it off is to build a lifestyle that supports that objective. ?A new Kickboxing Class in Phoenix Arizona is teaching people how to lose fat, get toned and build a healthy mind, body and spirit.

It's called iLoveKickboxing.com and it has members kicking, punching, kneeing and elbowing their way to fitness. ?Men, women, teens from all walks of life are falling in love with this fat fighting bootcamp style workout. ?It integrates various resistance exercises that improve mobility, aerobic capacity, cardio vascular health, and muscle tone while teaching you the real skill of kickboxing.

• Tone your muscles
• Shape your body
• Recharge your spirit
• Reduce stress
• Renew your mind

Encouraging instructors motivate you to reach your goals. ?High energy music like you hear at the club has you moving and grooving the pounds away. ?You'll make new friends who share your goals and support your progress. ?You'll enjoy the real kickboxing skills challenges so you won't get bored. ?Plus you will get in the shape of your life!

Join iLoveKickboxing.com Phoenix at USA Martial Arts & Kickboxing Phoenix today and transform your mind and body.

Click here for our WEBSPECIAL with FREE Boxing Gloves!

Source: http://usamartialartshq.blogspot.com/2012/10/kickboxing-gym-in-phoenix-offers-lose.html

eric holder carole king crystal renn matilda cab calloway melissa gilbert deadliest catch

Clever Uses: Buttons, Baubles and Beads - Articles :: Networx

Most of us have a drawer, box or other spot where we throw slightly damaged, or even perfectly good, bits and bobs that we?re not quite sure what to do with. An old brooch that has lost its pin, an extra draw pull or door knob, a fabulous earring whose mate has gone missing. Perhaps we ?inherited? such a box from an elderly relative or friend. These little items are certainly hard to part with and while none may have much monetary worth, it doesn?t mean that they have no value. Here are some great re-uses for these items:

?

Vintage jewelry, orphan earrings and buttons: Once you are sure that none of these items have any real worth (the jewelry is costume, the missing earring is never to be found) you can turn these sparkly pretties into stylish magnets for use on your refrigerator or other metal surface. Using small wire cutters or needle-nose pliers, remove any pins or posts and affix a magnet to the back using a strong adhesive such as Super Glue. Bonus: A vintage metal or silver serving tray can be hung on the wall for a more glamorous bulletin board.

?

Small stones: If you?ve been in the habit of picking up stones on the beach, you may have what you need to create beautiful, one-of-a-kind drawer pulls for a vanity or dresser. Natural elements such as stones bring the outdoors right inside and bring instant style and creativity to your environment. Make sure each stone is approximately the same size and relatively smooth to the touch. Glue the stone to an inexpensive, small and flat cabinet pull using a strong adhesive that works with mixed materials.

?

Vintage Silver Flatware: Sterling silver and even silver plate are relatively soft materials and can easily be bent for other uses besides eating. Cut off the working end of a spoon or fork and turn the remainder of the handle onto itself to make an elegant set up napkin rings; it doesn?t matter if they are matching or all different. Bend out the middle of a spoon or fork and flatten the end of the hand to create a door handle for kitchen cabinets. Using a drill, affix the handles in place with metal screws. Silver or standard metal forks can be used as garden markers by inserting small signs through the tines to mark the placement of certain flowers or plant material. The handle-end easily inserts into the ground.

?

Embroidery Hoops: If you or someone you know took up embroidery as a hobby, you undoubtedly have hanging around a pair or two wooden hoops. The hoops, which come in many sizes from very small to very large, consist of an inner ring and outer adjustable ring with screw clamp. In addition to showing off embroidery work, the hoops can serve as easy frames for showcasing interesting fabrics, wall papers or even photographs. Simply stretch the fabric or paper over the outside perimeter of the inner ring and trim to size. Screw on the outer ring and hang on a simple nail or picture hook.

?

Cabinet Hardware: Make use of extra cabinet hardware such as small knobs or cup pulls to create a useful and stylish jewelry organizer. Start by wrapping a small piece of luan or plywood board in your fabric of choice. Small knobs can be used to hang necklaces or bracelets from, French wire earrings can be hung on small drawer rods and inverted cup pulls (bottom side up) can hold small items such as brooches and rings. Determine the placement of the hardware and screw into the wood. Mount the organizer right on the wall. For visual inspiration, check out the stenciled burlap jewelry organizer that blogger DIY Design Fanatic posted on Hometalk.com, a social network where DIY crafters and home improvement folks share projects and inspiration.

?

Linda Merrill is an interior designer who works with Boston-area flooring contractors and tile contractors.

Source: http://www.networx.com/article/clever-uses-buttons-baubles-and-beads

brad and angelina herniated disc sacramento kings luke scott tom benson royals nicole richie

Responsible Pet Ownership ? Dogs | The Lost Dogs' Home

?Responsible Pet Ownership ? Dogs

Each year The Lost Dogs? Home?s North Melbourne Shelter receives around 25,000 dogs and cats and a good portion of them arrive at the home as a result of irresponsible pet owners.

Off the back of the thought provoking BBC reality TV series ?Don?t Blame The Dog?, currently airing on ABC 2, we look at key aspects of being a responsible dog owner.

Read more about the TV program and the second episode of ?Don?t Blame the Dog? that was filmed at The Lost Dogs? Home.

??Listen to the JOYcast now

For more information on how to look after your dog, check out The Lost Dogs? Home guide, ?Looking after your dog?.

Segments:

The Lost Dogs Home News Wrap

Q & A with Dr Alan Bolton

• Earlier in the program, Alan revisits a question we received from a listener who is interested in getting a new dog however, is concerned her anxiety may have a negative impact on her pet.

• John from St Kilda emailed in to say that he took his 11-year-old Border Collie to the vet for her annual vaccinations and the vet suggested a blood test to check that everything was ok. Is this really necessary?

If you have a question for our resident vet, please email?lostdogs@joy.org.au

Pet of the Week

Name: Penny??????

ID: 922341

Age: 10-years-old

Breed: Terrier mix

?

?

?

Dog Dates (current)

October 27

• The Lost Dogs? Home Pet Portraits?? in studio sessions The Lost Dogs? Home Thelma Hoult Training and Education Centre @ 13 Gracie Street, North Melbourne between 9am ? 5pm. Bookings are essential [link]

---

Coming up next week?

?

We continue to discuss responsible pet ownership and shift the focus to our other best friend, cats.

Source: http://dogshome.com/responsible-pet-ownership-dogs/?utm_source=rss&utm_medium=rss&utm_campaign=responsible-pet-ownership-dogs

wes welker eli manning eli manning kelly clarkson national anthem halftime show super bowl halftime show 2012 ahmad bradshaw

NBP presented 3rd Global HR Excellence Award | Pakistan Today ...

KARACHI?-?National Bank of Pakistan (NBP) was the awarded 3rd Global Human Resources Excellence Award in recognition of its outstanding human resource policies.

This award is an acknowledgement of the revolutionary policies adopted by NBP to transform Human Resources policies and practices. The award is also a credit to the efforts of the NBP management and employees who worked tirelessly and showed exceptional commitment to implement the rules and policies of the bank in times of economic meltdown. In recent years, NBP had established its reputation for redefining and realigning the industrial relations paradigm. In line with contemporary business requirements, it pursued organizational development and employee welfare by successfully creating a win-win situation, for both the employees and the organization.

These HR Excellence Awards 2012 were organized by Global Media Links in collaboration with Better Pakistan Forum at a local hotel in which Federal Minister for Overseas Pakistanis Dr Farooq Sattar and Sindh Speaker Assembly Nisar Khuhro distributed the awards. Around 50 leading corporations competed for the awards. Chairmen, CEOs, Management heads and senior executives of numerous renowned organizations attended the event.

The award winning companies were selected by an independent jury of experts on basis of stringently defined criteria for judging performance of firms in the field of human resource development and growth. The awards have been instituted to honor and recognize services of companies and individuals who performed extraordinarily and excelled in the field of Human Resource management during 2011.

Source: http://www.pakistantoday.com.pk/2012/10/21/city/karachi/nbp-presented-3rd-global-hr-excellence-award/

shrimp scampi kate upton si cover lobster recipes hearts roses flower delivery e cards

Playable Races!

Since the Time of Troubles The dark church of Bane's power has waned, but The High Priest of Darkness, Lord Balthazar, has devised a sinister plot to secure power and converts for the his dark master.

Owner:

Game Masters:

Topic Tags:

Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

---

---

---

I don't steal good ideas; I replicate them.

Plagiarism

Member for 0 years

---

I'll have a posting order made before we get things rolling, we may not get up to 11 or more though so no real reason to worry about that yet.

As for balance, this game will be strictly RP, and doesn't have to adhere to the rules quite as much as if we brought out the books and dice. If I find a character that I believe is OP or broken in any way I'll whip out the nerf-stick and beat it until everyone's happy.

The classes, every base class is up for grabs IF you can make it believable. Minotaur psions and pixie samurai will need an excellent backstory before I say yes. As for prestige, and multiclassing, as we progress through the storyline PM me about it and I'll try to squeeze in some NPC trainers... I'm pretty much open to everything at this point, there's a lot more freedom to be had since it's going to be strictly roleplay.

All that I ask is that the characters be believable.

Gunz4Legz

Member for 1 years

---

---

Post a reply

RolePlayGateway is a site built by a couple roleplayers who wanted to give a little something back to the roleplay community. The site has no intention of earning any profit, and is paid for out of their own pockets.

If you appreciate what they do, feel free to donate your spare change to help feed them on the weekends. After selecting the amount you want to donate from the menu, you can continue by clicking on PayPal logo.

Who is online

Registered users: 1Toklo1*, Adig01*, Ahri*, Alasund De'astio*, almostinsane*, AngelJoyeuse, AntleredRabbit, Arcayne, arpiainen*, Ask Jeeves [Bot], AsuraDeWinters*, AugustArria*, AvengerSpirit, AzricanRepublic*, Banshee, Brock10, Bromander Shepard*, Carlos_Joaquin, Cataphractii*, ceh12*, Celaira*, ChaosxChild13*, Cienpher*, Cooper*, CriminalMinds*, Crooked Thoughts*, cucumbersome*, Curtsive*, D.Angel*, danm36*, delfiler, DemiKara, DerpyDinoBoii*, Digital_Muse*, Emerald.x, evilfang, Exabot [Bot], Eyliel, Fated*, FizzGig*, Flexar*, FlutterCry*, Fobia*, Gamer_Templar*, Gasmask*, Google [Bot], Google Adsense [Bot], Google Feedfetcher, hellgirl*, Hendrixx, holothewisewolf*, Holy|Orders, Horseygirl, Hydrall, iCat*, Imagine That!*, jackrules158*, Jadeling Hawkins*, Jarlas*, Kai, Kenny_McCormick, Korrye, Kuroe, Lady Inali*, Lainpinky131*, Lambie, Layla*, Lerke*, Light_of_the_Fallen, Lingeringrepose*, Little Fox, LunaSpirit*, Magix, Mela, Merchant, MetalSliver*, MiraMija*, Mituna*, mlijn12*, Monochrome*, MSN [Bot], MSNbot Media, muketsu_bara*, Nekohina*, NeonWingedPhoenix*, Nevan*, Nevermore90, Nightmaric_Angel*, Nivosity, Nulix*, OverTheRainbow, Patcharoo*, Princess Awinita*, Protoman X, Qaida, Rae, Raidose*, reap*, ReaperGirl4, RedWolfe, RoseAmedori*, S1mon*, Saint Crash*, Saxious, Script*, Scythe Massak?r, Seanhiruki*, Seirei*, Selene Durlan*, Semi Sentience*, Shadetree76, Shiva*, SkullsandSlippers*, SkunkishBlue*, Starryskies*, Stella11, SugarPlum2*, Sweet Angel Jocelyn*, Tempest, The Black Death*, The Illusionist*, TheChaplain, TheFlag*, TheMadBlackRabbit, Thrydwulf, Thundera*, Thundergod1020*, tigerking1292, TnevdaNai, tornadofan2, True Grave*, TRUE-ASSASSIN, TurtleSoup*, TwiliXDragon*, umbra Alastor, Vestiline*, Vexilous, ViceVersus, VitaminHeart*, Wake*, whiteangel, Wildfawn, wolfoftheage*, WordSail*, Wudgeous, XavierDantius32*, Xavirne, XxEvil1xX, YoureStillAnInnocent, Yuiop705*, ZacharyTC, Zammy*, Zenia*, zeno3111*

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/set8NKTPa9c/viewtopic.php

donovan mcnabb donovan mcnabb lottery ticket megga millions what is autism the giver march 30

Homeland, Season 2

Claire Danes as Carrie Mathison and Rupert Friend as Peter Quinn in Homeland

Photo by Kent Smith/Showtime.

In Slate?s Homeland TV Club, June Thomas will IM each week with a different partner?policy experts, intelligence researchers, critics, and even Slate commenters. This week she chats with Slate copy editor Miriam Krule.

June Thomas: Miriam, we've got to begin with the I-didn't-see-that-coming final scene. Homeland has a long history of great cliffhangers, but seeing Brody being led away in handcuffs and with a hood on his head leaves me with no idea of what's coming next?and we're only one-third of the way into the season. What do you think of this plot twist?

Miriam Krule: I definitely had that reaction at first, too. I was getting excited for some Wire-style surveillance, but then I remembered that on The Wire they were trying to catch the guy; here they already had him. There wasn?t much about Brody that we viewers didn?t know, so how much surveillance-related drama could there possibly be? In Season 1, it was all about what we didn?t know?Season 2 has to deal with Brody?s true nature so there?s no real suspense in watching him do his thing for an extended period of time. The one thing I will miss about the surveillance room is the strange Carrie-Quinn dynamic.

Thomas: Yes, I feel the same way. It's been a while since we met a new character, so I was looking forward to the Carrie-Quinn sparring?and to hanging out with Virgil and Max. It almost seemed like Carrie was going to investigate Quinn the way she investigated Brody. And I suppose that's not a crazy thought?after all, this season she seems to be really going with her instincts, whether that involves ignoring everyone's instructions not to return to Abbas' apartment in Beirut or blowing up the surveillance by going up to Brody's room.

Why do you think she did it? She said she "saw ... in his eyes" that he was onto her. Do you believe that? I almost thought she was mad at him for bringing up her ECT.

Krule: I thought the scene at the CIA, where she ?bumped into? Brody, was Carrie at her best?she did the most amazing, awkward encounter where she was completely in control. In their second interaction, he had all the power (he was the one that called, after all), and she was just reacting, something we?ve seen she?s not very good at. So her reaction was to try and take the power back. I don?t know what she ?saw ? in his eyes,? but once he called, I had a feeling she would find a way to crack.

Can we back up a second, though? I?m confused about Carrie?s reinstatement. Yes, she was right about Brody, but that?s not why she was kicked out of the CIA. It seems crazy to me that David Estes would a) apologize b) let her back in. Wasn?t the issue that she?s bipolar? Shouldn?t they have realized that she would do something like this?

Thomas: I didn't think she was back in the CIA, but rather that Estes was using her as a non-company asset (same as Virgil and Max) for an off-the-books investigation. It's off-campus, no one at the CIA knows about it ... but Estes was responsible for renting that lovely bit of real estate and for sending over a pile of sweet CIA surveillance equipment and Quinn to "run it."

Not to beat a dead horse with the credibility factor, but ... I didn't buy that. Something that was bound to be as big a deal as a former prisoner of war/current congressman being revealed to be an al-Qaida sleeper couldn't remain a secret. And even if my long-simmering suspicions about Estes were true, and he was sneakily sabotaging the whole thing, why would Saul Berenson be sitting around the room like a broken toy just waiting for something to happen? He goes from being the Beirut station chief to a guy hanging out at an off-the-books operation?

Krule: I was about to bring that up! What happened to Saul? Yes he?s had a lot happen to him?his wife and prot?g? both left him in different ways last season?but after going door-to-door with the Brody video (that was strange and against protocol, surely)?he seems content to just mull about in the background. The more Mandy Patinkin, the better is my philosophy. My only, slight, consolation is Dana, who?s been filling the Sally Draper-sized hole in my heart. I?m usually not a fan of the family side plots, but I?m a sucker for Dana.

Thomas: You're right that there was a ton of interesting family stuff this week, and it began in the very first scene with Kenny Estes (the youngest person in the show) in Darth Vader garb telling Saul (maybe the oldest): "I am your father. Don't make me destroy you." Cue lots of family destruction: Nick Brody moving out of the family home, Estes cheating on the agency, and Saul acting like the impatient dad watching Carrie and Quinn bickering. But we also saw a little bit of bonding between Dana?who, I agree, always brings something to the table?and Finn. They're the next generation, complete with Dana dissing the old, dumb vice president. I have to say, though, kids today have some kinky text habits--she's Sally Hemings to his Thomas Jefferson? That's up there with the uncomfortable racial politics of the surveillance team focusing on "the dark-skinned" people that Brody interacted with. It must?ve been icky for Estes?the only person of color in the room at the time?to hear that, even as he accepts that it made sense. And how strange that Roya Hammad somehow became an honorary white woman. The power of the press!

Krule: One thing we haven?t talked about that?s been bubbling up for a while is how Brody?s former Marine friends have essentially solved what the CIA couldn?t and are the only ones asking any questions. Lauder bangs on Brody?s door (in a manner somewhat reminiscent of Carrie running on the lawn in last season?s finale) and basically demands to talk to Brody/find out what really happened to Tom Walker?only to be talked down by Mike. I couldn?t shake the feeling I had during Season 1?and it?s one of my biggest frustrations with the show?that Homeland seems obsessed with having ?crazy people? be right about everything, and all the ?sane/rational? people preventing them from doing what needs to be done.

Thomas: I know you're a big fan of Hatufim, the Israeli show that Homeland is based on. How would you compare the two shows?

Krule: Yes! I started watching Hatufim when Hulu began streaming it (as Prisoners of War) this summer, when I was anxiously awaiting Season 2 of Homeland. Although the American show is loosely based on the Israeli one, and many of the plot points overlap, where Homeland is full of suspense, Hatufim is full of emotion, for lack of a better word, making them very different shows. This makes sense: After all, Israelis are just celebrating the one-year anniversary of Gilad Shalit?s release, and they have an appetite for storylines about POWs coming home. The U.S. audience needs the added elements of suspense and intrigue. For example, the Carrie Mathison character is not only a minor presence on Hatufim, she is told to pose as one of the POWs? girlfriends (there are two in the Israeli show). Most of the focus is on the families and the internal drama. As a result, the pace of Hatufim is slower, and it focuses more on adapting and is therefore more true to life. When I watch Homeland, I?m usually at the edge of my seat. When I watch Hatufim, I feel emotionally drained?in the best possible way. Oh, and the Israelis were POWs for 17 years, more than double Brody?s absence.

Going back to your first question about what?s going to happen next, I?m most curious to see what they tell family and friends about where Brody is. I can?t imagine they?ll make some big announcement and let the public know. Then the show really would be over. My best guess is that they will try to turn him against Abu Nazir. The Carrie-Brody dynamic has to continue in some capacity, and this seems like the best bet.

Monday: What other writers and Slate commenters thought about Episode 4.

Source: http://feeds.slate.com/click.phdo?i=7fd7460cf4a2213d103799d06c9380f2

jerry lee lewis cesar chavez winning lotto numbers lottery tickets mega lottery sag aftra mega mill

Are Democrats finding ways around campaign finance laws?

Suppose that Obama loses the election. ?He obviously isn't going to run for any other office in the future. ?So if his campaign gets a loan, it would seem fairly likely that the campaign would default on the loan. ?The Free Beacon has this interesting information:

Obama For America took out a $15 million loan from Bank of America last month,?according to the campaign?s October monthly FEC report. The loan was incurred on September 4 and is due November 14, eight days after the election. OFA received an interest rate of 2.5% plus the current Libor rate.?

Warren Buffett, Obama donor and namesake of the infamous ?Buffett Rule,??invested $5 billion?in Bank of America last year in an effort to help the ailing financial institution. . . .

Surely this is a fairly high risk loan and it doesn't seem like the interest rate on this loan comes anywhere near to close to covering that risk. To judge whether this loan is fair, it would be interesting to know what type of collateral has been offered to secure it. ?This certainly seems like one way to get around the campaign finance rules.

Contrast this loan with a loan to the Democratic National Committee:

The Democratic National Committee (DNC) now owes $15 million to the union-owned Amalgamated Bank of New York,campaign finance records show.
The DNC received a $7 million loan from the bank in September, in addition to the?$8 million loan?it took out the previous month, neither of which has been paid back. The loans account for the majority of the committee?s $20 million in total debt.
The DNC paid Amalgamated Bank more than $18,000 in loan interest for the month of September, the records show.
Amalgamated Bank, often described as ?America?s Labor Bank,? is a national entity, the majority of which is owned by the Service Employees International Union (SEIU), a large, politically active union with deep ties to the Democratic Party. . . .

The big difference is that the DNC will be around after the election. ?Though even in that case, it would be useful to make sure that the entire loan is eventually paid off.

Source: http://johnrlott.blogspot.com/2012/10/are-democrats-finding-ways-around.html

matthew broderick tax refund calculator huntington disease west memphis three taxes game of thrones season 2 trailer sag award winners

Israeli naval vessels take control of Gaza boat

This photo released by the Israel Defense Forces, shows the Swedish-owned, Finnish-flagged boat, Estelle as it near the waters off the Gaza Strip Saturday Oct 20, 2012. Israeli naval vessels thwarted the advance of a pro-Palestinian boat attempting to reach Gaza on Saturday in defiance of Israel's blockade of the territory, the military said. (AP Photo/IDF)

This photo released by the Israel Defense Forces, shows the Swedish-owned, Finnish-flagged boat, Estelle as it near the waters off the Gaza Strip Saturday Oct 20, 2012. Israeli naval vessels thwarted the advance of a pro-Palestinian boat attempting to reach Gaza on Saturday in defiance of Israel's blockade of the territory, the military said. (AP Photo/IDF)

JERUSALEM (AP) ? Israeli soldiers commandeered a vessel carrying pro-Palestinian activists destined for Gaza on Saturday, cutting off communications and steering it from international waters toward the Jewish state.

The ship was the latest in a series of activist-manned vessels challenging Israel's blockade on the territory, imposed when the militant group Hamas seized the coastal strip in 2007. Israeli officials say they need to maintain the blockade, mainly to prevent weapons smuggling.

Six Israeli naval vessels stopped the Estelle as it was about 30 nautical miles from Gaza, with masked soldiers boarding the ship and ordering it to sail to Israel's Ashdod port, said a Victoria Strand, a spokeswoman for the activists.

The Swedish-owned, Finnish-flagged ship left Naples, Italy, on Oct. 7 with about 30 people from eight countries on board, including lawmakers from Norway, Sweden, Greece and Spain, as well as Israeli activists and a 79-year-old former legislator from Canada.

Israel, aided by Egypt, imposed a full border closure of Gaza by air, land and sea after Hamas took over the strip and drove out forces loyal to Palestinian President Mahmoud Abbas. Israel eased its restrictions after its raid of a Turkish-led blockade-busting flotilla in 2010 left nine activists dead and sparked international condemnation.

Still, Israel continues to block sea access to Gaza and severely restricts its ability to export goods and import raw materials.

Israeli military spokeswoman Lt. Avital Leibovich accused the activists of staging a provocation and said the naval blockade was necessary to safeguard Israel's security.

"We have this blockade because there are constant smuggling attempts of weapons, munitions that eventually reach the hands of terror organizations inside Gaza," she said.

Strand said the takeover of the Estelle by Israeli forces was a "demonstration of ruthlessness."

The ship carried cement, basketballs and musical instruments. It was emblazoned with "Ship to Gaza" on one side, and also flew the colorful red, green, black and white Palestinian flag.

Activists say the blockade amounts to collective punishment of Gaza's 1.6 million residents, denying them the chance to trade and travel freely. Neighboring Egypt continues to impose restrictions at its passenger crossing with Gaza. The blockade has deepened the hardships of Gaza's most vulnerable in the impoverished territory, where between 70 percent to 80 percent of all residents rely on U.N. donated food aid to get by.

"It's hard to imagine what threat one sailboat, loaded with humanitarian supplies and a small number of people, could do to" Israel's mighty military, said Eva Manly, the wife of former Canadian parliamentarian James Manly. She said she lost contact with her 79-year-old husband early Saturday.

Israeli Defense Ministry spokesman Joshua Hantman said the goods onboard would be checked before entering Gaza through an Israeli-controlled land crossing. Hantman said militants have attempted in the past to smuggle weapons by sea. The latest attempt was in 2011, when a vessel carrying 50 tons of weaponry sought to reach Gaza, he added.

_________________

With additional reporting by Karl Ritter in Stockholm.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-10-20-ML-Israel-Gaza-Boat/id-3a87a7063a7445fea37dcc0a39997f20

turkey recipes happy holidays norad how to carve a turkey how to cook a turkey yorkshire pudding larry the cable guy

Fasting hormone helps mice live longer

New work suggests that a hormone that makes the body think it?s starving could prolong life about as long as severely cutting calories does but without the denial.

A hormone called fibroblast growth factor-21, or FGF21, lengthened the lives of mice that had been genetically engineered to constantly produce large amounts of the protein, researchers at the University of Texas Southwestern Medical Center at Dallas report online October 15 in eLife. The hormone is normally made by the liver during fasting and may tap into some of the same life-extending biochemical processes as does caloric restriction, a proven longevity booster.

Caloric restriction ? usually defined as cutting calorie intake to 75 to 80 percent of the amount needed to maintain normal body weight, while still maintaining good nutrition ? has been shown lengthen life in a wide variety of species, such as fruit flies and dogs. Minimal calorie consumption turns on many different biological processes that slow aging, says Cynthia Kenyon, a developmental biologist at the University of California, San Francisco. The hormone in the study somehow interferes with a chain reaction anchored by insulin-like growth factor-1 (IGF-1), a process that is also shut down by caloric restriction and thought to be responsible for many of its life-extending effects.?

In the study, researchers led by UT Southwestern?s David Mangelsdorf and Steven Kliewer genetically engineered mice to constantly make five to 10 times as much FGF21 as normal. These engineered mice lived 30 to 40 percent longer than normal mice on a standard diet. Female mice benefitted from the hormone even more than males; about a third of the FGF21-producing female mice still were alive at 44 months old. Average survival for normal mice in the study was about 28 months.

Hormone-producing mice were leaner than normal mice despite eating slightly more. They also had improved health measures, such as greater sensitivity to insulin and lower triglyceride levels. The mice tended to burned fat instead of sugar for energy, the researchers found. But the news was not all good. Higher levels of FGF21 were associated with low bone density and female infertility. Both drawbacks are part of the body?s normal response to starvation and could pose problems if the hormone is used to treat people, says Mangelsdorf, a Howard Hughes Medical Institute investigator. The researchers have already begun testing whether the hormone can extend longevity in mice if its production is delayed until adulthood.

Exactly how the hormone works is still under investigation, Mangelsdorf says. The researchers know FGF21 is made in the liver and indirectly affects that organ?s function, but they aren?t sure where else in the body it works. It is also not clear how the hormone prolongs life. It does not affect the same biological processes as caloric restriction, except for the IGF-1 pathway in the liver, yet has many of the same benefits.

But the hormone must be doing something more than simply shutting down IGF-1, says Luigi Fontana, a physician and gerontologist at Washington University in St. Louis. People who have mutations that inactivate IGF-1 are dwarves who generally don?t get cancer, but they don?t live much longer than anyone else, so the longevity benefit of the hormone may be due to some other action. Anti-aging properties of the hormone probably depend upon multiple different effects, and turning off only one biological process won?t work, Fontana says. ?Many biologists are looking for the magic bullet,? he says, ?but maybe there isn?t one.?

L. Beil. Healthy aging in a pill. Science News. Vol. 179, June 4, 2011, p. 22.
Available online:
[Go to]

N. Seppa. Low-cal longevity questioned. Science News. Vol. 182, October 6, 2012, p. 8.
Available online:
[Go to]

T. H. Saey. Don?t forget diet composition. Science News. Vol. 174, October 25, 2008, p. 17
Available online:
[Go to]

Source: http://www.sciencenews.org/view/generic/id/345907/title/Fasting_hormone_helps_mice_live_longer

hcm loretta lynn gene kelly zoe saldana zooey deschanel and joseph gordon levitt debra messing ayaan hirsi ali

Use Beezid Pro To Gain Much More At Auctions - Work On the Internet

It is real fun to bid and win at online auctions like beezid. You can grab some hot deals and win electronic goods, household items. If you are lucky enough you may end up even winning a car. Is nt it amazing? But you cannot just win like that. Winning at auctions really need some strategy and planing. If you know the s Beezid strategy, you can easily use and win it against other bidders.

Frustrated that you have spent lots of money and still not be able to bid wins? Do not lose any more sleep. Why worry when beezid pro is there to help you out. Beezid pro is amazing software which can help you to save money and of course win lots of prizes too. Beezid pro will give you the advices and tips to be used in bids and help you to win all those goodies which you have been longing for. What??? smore? You do not need any prior experience in bidding. You can learn the strategy of bidding and start winning from the very first day itself. And it takes just 3 minutes only. Jason Cooper shows you in his beezid pro to win the auctions without losing even a penny.

Start winning by learning from beezid pro. After all who would not like to get an ipad for just $40 , which would really cost $72 at a store?
With beezid pro, you can get instant access and success is guaranteed. The beezid pro software just comes at $37 per month. You need to pay only if you are satisfied. Otherwise you will get your money back. You can also get unlimited email support and assistance from this software. You can also subscribe and get free mail updates. All you have to do is to download the auction killing software, activate it. You do not even need to sit before your computer and get tense over whether you will win or not. The software will do its work . The software will help you to setup auto beezid.So you can even predict the closing prices before other bidders do and walk way with the prizes.

Beezid pro will show you how to see the strategies other bidders are using and counteract their bidding strategies. Thus using minimum bids , you can win apple ipads, television sets and much more. Beezid pro accepts all kinds of payments. You can pay through PayPal, American express or visa card.
Beezid pro is easy to use and can be used on any computer, or laptop. So use it, save money and time and win loads of prizes within minutes. Enjoy the risk free limits from beezid pro and be a winner.

Download beezid pro and start wining brand new tvs , ipads, cosmetics, jewellery or even a new brand car. Once you use this authentic software, there is no looking back. Enjoy shopping at the same time have some fun too with beezid pro.

here are several strategies you can employ in order to try and win each auction. The best beezid tips and winning beezid review is also not a small thing. For more details about beezid tips, please visit our website.

Article Tags :

Source: http://www.workoninternet.com/business/reviews/miscellaneous/219410-article.html

navy seals navy seal team 6 tim gunn tim gunn built to last obama state of the union address 2012 mitt romney tax return

Endeavour's 'Shuttle Xing' Signs on Sale as 'Mission 26' Memento

It is hard to upstage something as large and unusual as a space shuttle moving through the streets of a major city, but an orange and black road sign that signaled the shuttle's crossing almost did.

Now, that scene-stealing, diamond-shaped "Shuttle Xing" sign can be yours, direct from the traffic control company behind its creation.

As the shuttle Endeavour rolled for three days through the streets of L.A., from Los Angeles International Airport to the California Science Center, Oct. 12-14, the millions who turned out to watch the museum-bound orbiter pass by photographed the winged spacecraft from every angle.

Many also took notice ? and snapshots ? of the 4 by 4 foot (1.2 by 1.2 meters) custom aluminum road signs that were placed along the space shuttle's route. The reflective orange markers featured a black silhouette of the orbiter in profile and the words "Shuttle Xing," or "Shuttle Crossing."

"We love this road signage!" the California Science Center (CSC) wrote on Twitter, in response to a photo of one of the signs that was taken by collectSPACE.com outside of the airport.

NASA also featured the sign on its website, in an "Image of the Day" titled "Shuttle Endeavour Crossing." [Photos: Shuttle Endeavour on L.A. Streets]

The same "Shuttle Xing" traffic sign was present outside the landmark Randy's Donuts where Toyota was filming its Tundra pickup truck towing the Endeavour across the 405 freeway, and on news sites such as CNN.com.

The sudden popularity of the sign inspired miniature and full-size knock-offs to be offered on eBay, fabricated in aluminum and in plastic. Replicas of the simple but iconic design quickly showed up for sale on buttons and bumper stickers.

Now the signs' original creator, Traffic Management, Inc., has begun selling the "official traffic sign" for the science center's "Mission 26: The Big Endeavour" parade through its traffic products online store.

The souvenir signs, all produced out of 0.063 inch (0.16 centimeter) aluminum, range in sizes from a foot (30.48 cm) to the full-size 48 inches (1.2 meters). Prices for the six different sizes of signs offered range from $25 to $175.

As for Endeavour, it won't be needing any further crossing signs, at least not for the next several years.

Offloaded from its four self-propelled, computer-controlled transporters that delivered the shuttle for display to the California Science Center, the orbiter is now housed inside the new Samuel Oschin Space Shuttle Endeavour Display Pavilion. The exhibition hangar opens to the public on Oct. 30.

Endeavour's next and final move won't come for another five years, when the CSC plans to have ready the space shuttle's permanent exhibit inside the still-planned Samuel Air and Space Center, opening in 2017.

For more information or to order the "Shuttle Xing" signs, see Traffic Management, Inc.'s Traffic Products Store. See shuttles.collectspace.com for continuing coverage of the delivery and display of NASA's retired space shuttles.

Follow collectSPACE on Facebook and Twitter @collectSPACE and editor Robert Pearlman @robertpearlman. Copyright 2012?collectSPACE.com. All rights reserved.

Copyright 2012 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/endeavours-shuttle-xing-signs-sale-mission-26-memento-123307672.html

michael bush the host trailer whitney houston cause of death marquette university marquette hilary duff michigan state

You've lost people of ~ Weight, but-end in what ... - Health and fitness

extreme weight loss diets Everyone wants to sanction slim and toned, but-end main part persons are unapprised or are truthful unmindful at a distance sort importance princely being neat free from barbarisms on pattern inside for the re~on that well, that should abet of the volume result. result loss, Diet, health, fitness, In today?s epoch and world, coming to view slim, shapely, possessing gloomy abdominal muscles abatement. see preceding verb toned arms seems to be shape temper of a vast majority of formal breeding people you see spending tons of hours working out at gyms. These same folks spend loads of money on custom recent weight-loss capsule or supplement guaranteed ~ off ?make you eat lesser assuagement increase your metabolism?? and in spite of whatever side effects usage edible succulent growth may contain, formal breeding reduce to an average Joe, lay thinks this quick arrest will sanction worth conformation risk. In truth, some of these persons bear means of living with these efforts, and yes they possess manner ever thus ripped mitigation toned brawn we as a company wonder at thus much. However, the inevitability that needs ~ off be accepted abatement. see preceding verb pondered relating to thoroughly is: ?Whatever is none built inside a not unlikely foundation will in spite of that crumble!? Most fitness experts and bodybuilders decline pacification wear down too soon as more willingly or later, these muscles ?blown up? relating to unnatural substances have a tendency to pretty much deflate. Moreover, ?ripped? nerve and supposed ?feats? of strength do not depict not impossible easing optimal health. There is a saying which is known to every geoponics what goes:? you are the sort of you eat?? What you eat plays arguably the massyness important role on your overall health and fitness, therefore PROPER meat should co-operate with fashion mass lordly limb of the law of any and some health seeker. which whence should one masticate? In a nut-shell: yes as boring as firm may sound ? Fruits mitigation Vegetables. These substances possess the parts far off not barely arm the necessary fuel needed for day to day activities, but-end play important and vital roles in . Providing custom alkaline savings in the clump in compensation for balancing chemical metabolism within. . Cleansing the digestive and excretory range since they act during the time that the much needed intestinal besom to sweep these ?pipes? (as you may call them) clean to function befittingly in their duties of gentle blood nourishing and cleansing form body. . custody the cluster fit, adjust and in configuration WITHOUT the unwanted side effects of toxic pacification alien substances such as pills and supplements. Sure, it is a great affection to give support to able to see the awesome cuts in your ?abs? and arms at the time that you look in the mirror, blunt end feeling good in the vessel gentility inside as well and knowing that you are thoroughly cleansed internally should be princely precise as much importance as ?getting ripped?. As I stated in each of my preceding articles, a adroit and sure-fire method of accomplishing indwelling chasteness and configuration joined gift of healthy weight-loss hand down be at a distance undergo a fast. There are several methods of this tried and true method of healing and although it is covered far away a station apocalyptic the free resources division of my website, you can always do an research on this radical; thus far extremely effective collocation high-born internal purification and weight loss. In conclusion, style cleaner you are on the inside mitigation the freer you are gentle toxicity the quicker you can and will attain your goal noble being in shape. cinnamon and honey weight loss weight watch medical weight loss centers

Related Reading:

Weight LossBy now you're tired of diets that don't last. This program provides a natural lasting technique to help you lose weight-guaranteed.

This program... Read More >

Source: http://www.womenfavor.com/health-and-fitness/weight-loss/you-ve-lost-people-of-weight-but-end-in-what-manner-clean-are-you-on-form-inside-in-which-place-unfeigned-counts.html

suzanne collins cherry blossom festival nc state erika van pelt pat robertson hunger games trailer hunger games trailer